Both sides of the story How bacteria transfer through the blood–brain barrier?

Las dos caras de la historia ¿Cómo se transfieren las bacterias a través de la barrera hematoencefálica?

Authors

  • Adrian Macion

DOI:

https://doi.org/10.46932/sfjdv2n3-066

Keywords:

blood–brain barrier, bacterial pathogens, infections, cell junction

Abstract

ABSTRACT

Infections of central nervous system (CNS) still represent an important cause of mortality although globally abundance of antibiotics usage. Sepsis, bacterial invasion and microbial transversal of the Blood–Brain Barrier (BBB) are required to infect CNS. The latest research showed up that bacterial translocation through the BBB includes cytoskeleton rearrangements. Three different mechanism were described: paracellular, transcellular and Trojan-horse mechanism (in phagocytes). The consequences may be dramatic – disruptions of structure and loss of functionality of the BBB causing increased permeability, inflammatory and encephalopathy. Further experimental research should lead us to gain complete understanding of the host-bacteria interaction within microbial transversal of the BBB.

Published

2021-08-03