The utility of mean platelet volume delta (∆VPM) and mean platelet volume / platelet index as predictors of mortality in patients with Sepsis and Septic Shock


  • Serrano González America
  • Bautista López Federico del Jesús
  • Jimenez Ríos Eusebio



Sepsis, septic shock, mean platelet volume, medium platelet volume delta


Background. Sepsis and septic shock are the most severe clinical expressions of infection, despite having characterized several decades ago, remain as a diagnostic challenging and this can delay treatment and increasing hospital cost secondary to this pathology.

Our objective was to determine the usefulness of the mean platelet volume delta (ΔVPM) as a predictor of mortality.

Methodology. We performed an observational and descriptive study with 83 patients with Sepsis and / or septic shock criteria, from May 1, 2017 to August 1, 2017. Survival analysis was performed using Kaplan and Meier tables and was corroborated by the Long Rank test. The prognostic value through the proportional risk of Cox.

Results. Thirty-seven patients (44.6%) died because of the septic process. A univariate Cox regression analysis revealed a MPV / platelet index at admission of less than 4 was associated with a significant reduction in the risk of mortality from sepsis or septic shock at 60 days (HR, 0.236; 95% CI, 0.083-0.671; p = 0.007). The DVPM was not significantly associated with a reduction in the risk of mortality (HR, 0.373, 95% CI, 0.132-1.057, p = 0.640).

Conclusion. The platelet parameters are economical and available, providing diagnostic and prognostic results, avoiding costs, time and special tests. The VPM / PLQ index could be an effective "Alert System" in early sepsis.